DEPARTMENT OF MEDICAL BIOPHYSICS Institute of Physiology and Pharmacology

The research at the Department is oriented towards investigating the physiological and biophysical properties of hipppocampal neurons. Two main lines are present: (1) mechanisms of synaptic plasticity and (2) mechanisms of cell damage. Experiments are performed on acutely isolated or cultured slices of rat hippocampus. The techniques include: extracellular and intracellular electric recording of spontaneous and evoked synaptic responses, biochemical assays using HPLC to analyse neuroactive substances released form the slice, fluorescence staining and imaging.